張義國，學者主頁-中國科技論文在線

張義國

1) 跨膜糖蛋白轉錄因子Nrf1之抗氧化保護的細胞核膜生物學功能與生化機制；2) Nrf1跨膜拓撲學與基因調控在所致的非酒精性脂肪性肝炎惡化為肝癌中的分子病理生理學機制；3)紫外線誘導的皮膚癌變之細胞信號傳導的網絡調控機制；4) 癌變分子病理學與宿主分子免疫保護、化學預防。

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姓名：張義國
目前身份：
擔任導師情況：
學位：
學術頭銜：

博士生導師
職稱：-
學科領域：

光學
研究興趣：1) 跨膜糖蛋白轉錄因子Nrf1之抗氧化保護的細胞核膜生物學功能與生化機制；2) Nrf1跨膜拓撲學與基因調控在所致的非酒精性脂肪性肝炎惡化為肝癌中的分子病理生理學機制；3)紫外線誘導的皮膚癌變之細胞信號傳導的網絡調控機制；4) 癌變分子病理學與宿主分子免疫保護、化學預防。

個人簡介

張義國博士教授

歡迎：有理學、生物、或醫學背景的學生及青年科技愛好者，申報碩士、博士、博士后，從事真正科學研究: 細胞生化, 癌癥基因調控, 以及拓撲生物學.，探索科學真諦。請聯系：Email: yiguozhang@cqu.edu.cn ; y.z.zhang@dundee.ac.uk

學習工作簡介：

2010.07-現在：重慶大學 (與三軍醫大) 生物醫學工程聯合學院教授。

2008.01-2012.10：英國Dundee大學醫學研究院癌瘤研究系高級研究員(CO-PI);

2006.10-2010: 鄭州大學生物工程系兼職教授；

2003.05-2007.12: 英國Dundee大學生物醫學研究所高級研究專員(Senior Scientific Officer) , 同期在職攻讀細胞生化的哲學博士。

2007 被選為英國皇家醫學會會士（FRSMed）。

1999.07-2003.04: 美國明尼蘇達(Minnesota)大學Hormel研究所Fellow；

1995.07-1999.06: 河南醫科大學病理生理學講師；

1992.09-1995.06: 河南醫科大學病理生理學碩士研究生

1984.08-1992.08: 鐵道部四局醫院基層住院醫師、主治醫師。

研究經歷：

1995年獲河南醫科大學醫學碩士后留校即任講師，從事單克隆抗體及抗癌疫苗制備和應用研究。1998－2003年間，于美國明尼蘇達(Minnesota)大學，率先研究A類紫外線(UVA)誘導癌變與細胞信號傳導網絡的分子機理。之后，在英國丹迪(Dundee)大學獲細胞生化的哲學博士 (PhD)，留校做CO-PI研究員, 開創了核膜轉錄因子Nrf1及基因調控與癌變的機制研究。2007年被選為英國皇家醫學協會Fellow。曾任鄭州大學生物工程系教授，現任重慶大學生物醫學聯合學院教授。共發表90 多項出版物，其中65篇研究論文，多數發表于生物化學(JBC, BJ)和癌癥(Cancer Research，Oncogene,Carcinogenesis),及等一流專業研究期刊上。被SCI他引近2000次，H-指數20分。英文簡介( ).

研究方向：

1）細胞生化和拓撲生物學；
2）癌癥生物學與基因調控；
3）脂肪肝炎惡化為肝癌的分子病理學；
4）Nrf1抗老化與癌變機制及化學防治。

近期研究論文 (*corresponding author), 如下:

Yiguo Zhang*, Shaojun Li, Yuancai Xiang, Lu Qiu, Huakan Zhao, John D. Hayes (2015. The selective post-translational processing of transcription factor Nrf1 yields distinct isoforms that dictate its ability to differentially regulate gene expression. Scientific Reports_Nature.com. 2015 Aug 13; 5:12983, 1-30. doi: 10.1038/srep12983.

Chen J, Liu X, Lü F, Liu X, Ru Y, Ren Y, Yao L, Zhang Yiguo* (2015) .Transcription factor Nrf1 is negatively regulated by its O-GlcNAcylation status. FEBS Lett. 2015 Aug 19;589(18):2347-58. doi: 10.1016/j.febslet.2015.07.030. Epub 2015 Jul 29.

Zhang Yiguo*, Qiu L, Li S, Xiang Y, Chen J, Ren Y (2014).The C-terminal domain of Nrf1 negatively regulates the full-length CNC-bZIP factor and its shorter isoform LCR-F1/Nrf1β; both are also inhibited by the small dominant-negative Nrf1γ/δ isoforms that down-regulate ARE-battery gene expression. PLoS One. 2014 Oct 7;9(10):e109159.1-17. doi: 10.1371/journal.pone.0109159. eCollection 2014.

Yiguo Zhang*, Yonggang Ren, Shaojun Li, John D Hayes (2014) Transcription Factor Nrf1 Is Topologically Repartitioned across Membranes to Enable Target Gene Transactivation through Its Acidic Glucose-Responsive Domains. PLoS One. 2014 Apr 2;9(4):1-17; e93458. doi: 10.1371/journal.pone.0093458.

Michelle A Schultz, Sharika S Hagan, Amrita Datta, Yiguo Zhang, Michael L Freeman, Suresh C Sikka, Asim B Abdel-Mageed, Debasis Mondal (2014) Nrf1 and Nrf2 transcription factors regulate androgen receptor transactivation in prostate cancer cells.PLoS One. 2014 Jan 22;9(1):e87204. doi: 10.1371/journal.pone.0087204.

Yiguo Zhang*, Hayes JD (2013) The membrane-topogenic vectorial behaviour of Nrf1 controls its post-translational modification and transactivation activity. Sci Rep._Nature.com 3:2006 (1-16). doi: 10.1038/srep02006.

H Xiao, F Lü, D Stewart, Yiguo Zhang* (2013) Mechanisms underlying chemopreventive effects of lavonoids via multiple signaling nodes within Nrf2-ARE and AhR-XRE gene regulatory networks. Current Chemical Biology 7 (2): 151-176

Chowdhry S, Yiguo Zhang, McMahon M, Sutherland C, Cuadrado A, Hayes JD (2012-2013) .Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity. Oncogene. 2013 Aug 8;32(32):3765-81. Epub 2012 Sep 10. doi:10.1038/onc.2012. 388. PMID:22964642

Julia Li Zhong, Li Yang, Fenglin Lü, Han Xiao, Feifei Tian, Feng Zhu, and YIGUO ZHANG* (2011) UVA, UVB and UVC induce differential response signaling pathways converged on the eIF2a phosphorylation. Photochem. & Photobiol. 87, 1092-1104.

Yongjun Wu, Yiming Wu, Jiang Wang, Zhen Yan, Lingbo Qu, Bingren Xiang and YIGUO ZHANG (2011) An optimal tumor marker group-coupled artificial neural network for diagnosis of lung cancer. Expert Systems with Applications 38, 11329-11334.

YIGUO ZHANG* and John D. Hayes (2010). Identification of topological determinants in the N-terminal domain of transcription factor Nrf1 that control its orientation in the endoplasmic reticulum membrane. Biochem. J. 430, 497-510.

YIGUO ZHANG* (2009). Molecular and cellular control of the Nrf1 transcription factor: An integral membrane glycoprotein. Erschienen bei: VDM Verlag Publishing House Ltd, Germany in May 2009

YIGUO ZHANG*, Akira Kobayashi, Masayuki Yamamoto, and John D. Hayes (2009). The Nrf3 transcription factor is a membrane-bound glycoprotein targeted to the endoplasmic reticulum through its N-terminal homology box 1 sequence. J. Biol. Chem. 284, 3195-3210

YIGUO ZHANG*, John M. Lucocq, and John D. Hayes (2009) The Nrf1 CNC/bZIP protein is a nuclear envelope-bound transcription factor that is activated by tert-butyl hydroquinone but not by endoplasmic reticulum stressors. Biochem. J. 418, 293-310

YIGUO ZHANG*, John M. Lucocq, Masayuki Yamamoto, and John D. Hayes. (2007) The N-terminal homology box 1 (NHB1) sequence in transcription factor Nrf1 is required to anchor it to the endoplasmic reticulum and also to enable its asparagine-glycosylation. Biochem. J. 408, 161-172

YIGUO ZHANG*, Dorothy H. Crouch, Masayuki Yamamoto, and John D. Hayes. (2006) Negative regulation of the Nrf1 transcription factor by its N-terminal Domain is independent of Keap1: Nrf1, but not Nrf2, is targeted to the endoplasmic reticulum. Biochem. J. 399, 373-395

Tatyana A. Zykova, Feng Zhu, YIGUO ZHANG, Ann M. Bode and Zigang Dong. (2007) Involvement of ERKs, RSK2 and PKR in UVA-induced signaling transduction toward phosphorylation of eIF2a. Carcinogenesis 28, 1543-1551

Feng Zhu, Bu Young Choi, Wei-Ya Ma, Zhongliang Zhao, YIGUO ZHANG, Yong Yeon Cho, Hong Seok Choi, Akira Imamoto, Ann M. Bode and Zigang Dong. (2006) COOH-Terminal Src Kinase– Mediated c-Jun Phosphorylation Promotes c-Jun Degradation and Inhibits Cell Transformation. Cancer Research 66, 5729-5736

Yong-Yeon Cho, Zhiwei He, YIGUO ZHANG, Hong Seok Choi, Feng Zhu, Bu Young Choi, Bong Seok Kang, Wei-Ya Ma, Ann M. Bode, and Zigang Dong. (2005) The p53 Protein Is a Novel Substrate of Ribosomal S6 Kinase 2 and a Critical Intermediary for Ribosomal S6 Kinase 2 and Histone H3 Interaction. Cancer Research 65, 3596-3603

Tatyana A. Zykova, YIGUO ZHANG, Feng Zhu, Ann M. Bode, and Zigang Dong (2005). The signal transduction networks required for phosphorylation of STAT1 at Ser727 in mouse epidermal JB6 cells in the UVB response and inhibitory mechanisms of tea polyphenols. Carcinogenesis 26(2), 331-342

YIGUO ZHANG, Yong Yeon Cho, Brandon L. Petersen, Feng Zhu, and Zigang Dong. (2004) Evidence of STAT1 phosphorylation modulated by MAPKs, MEK1 and MSK1. Carcinogenesis 25, 1165-1175

YIGUO ZHANG, Yong-Yeon Cho, Brandon L. Petersen, Ann M. Bode, Feng Zhu, and Zigang Dong. (2003). Ataxia telangiectasia mutated protein, MAPKs and RSK2 are involved in the phosphorylation of STAT3. J. Biol. Chem. 278, 12650-12659

YIGUO ZHANG, Wei-Ya Ma, Akira Kaji, Ann M. Bode, and Zigang Dong (2002). Requirement of ATM in UVA-induced signaling and apoptosis. J. Biol. Chem. 277, 3124-3131

YIGUO ZHANG, Guangming Liu, and Zigang Dong (2001). MSK1 and JNKs mediate phosphorylation of STAT3 in UVA-irradiated mouse epidermal JB6 cells. J. Biol. Chem. 276, 42534-42542

YIGUO ZHANG, Ziming Dong, Masaaki Nomura, Shuping Zhong, Nanyue Chen, Ann M. Bode, and Zigang Dong (2001). Signal transduction pathways involved in phosphorylation and activation of p70S6K following exposure to UVA irradiation. J. Biol. Chem. 276, 20913-20923

YIGUO ZHANG, Shuping Zhong, Ziming Dong, Nanyue Chen, Ann M. Bode, Wei-ya Ma and Zignag Dong (2001). UVA induces Ser381 phosphorylation of p90RSK/MAPKAP-K1 via ERK and JNK pathways. J. Biol. Chem. 276, 14572-14580

YIGUO ZHANG, Peter Mttjus, Patricia C. Schmid, Zimng Dong, Shuping Zhong, Wei-Ya Ma, Rhoderick E. Brown, Ann M. Bode, Harald H. O. Schmid, and Zigang Dong (2001). Involvement of the acid sphingomyelinase pathway in UVA-induced apoptosis. J. Biol. Chem. 276, 11775-11782