目的 探討經顱磁電刺激(TMES)療法對海仁酸(KA)致顳葉癲癇鼠的療效。 方法 62只大鼠按照隨機數字表法分為預處理組(共32只)和治療組(共30只)，預處理組再分為4個小組，分別給予治療儀最大電流強度(MCI) 0%，25%，50%，75%的電流刺激，確定本實驗條件下的最佳刺激參數。治療組再分為3個小組，每組10只。2組(癲癇刺激組、癲癇非刺激組)為符合納入標準的癲癇模型大鼠，刺激組刺激參數為預處理組確定出的最佳刺激參數；非刺激組大鼠刺激前后處理與刺激組相同，但治療儀無有效的能量輸出。第3組對照組為未造模對照大鼠。3組大鼠均給予每天1次，40 min/次，共14 d的刺激。記錄并比較3組大鼠行為學、電生理學及組織學變化，以評估TMES療法對癲癇大鼠的療效。 結果 50%MCI為最佳刺激強度。癲癇刺激組大鼠癲癇波出現的頻率明顯低于癲癇非刺激組大鼠[(30.210 ±4.580)次/min vs. (31.380 ± 4.247)次/min]，差異有統計學意義(t=3.235，P=0.001)。Timm染色結果提示3組大鼠染色評分差異有統計學意義(F=17.429, P=0.000)，癲癇刺激組大鼠海馬齒狀回的內分子層Timm染色評分較癲癇非刺激組明顯減輕，差異有統計學意義(P＜0.05)。結論 TMES療法可通過改善癲癇大鼠海馬齒狀回內分子層組織學變化程度來影響齒狀回神經元環路的形成，進而降低癲癇腦電波的發作頻率。

This is a new idea that based on effective treatment of Parkinson's disease and Alzheimer's disease with transcranial magnetoelectric stimulation technology, it can understand a hypothesis about voltage-gated Ca2+ channels is the best target for activation by physical means, basic content：Parkinson's disease , Alzheimer's disease etc. neuronal degeneration diseases, that closely related to physical-gated ion channels, which can be treated with physical means, activating neurotransmitters-energic neurons plays key roles in the treatment, and voltage-gated Ca2+ channels is the best target for physical means, the purpose is to induce Ca2+ inflowing and triggers neuronal axon terminals synaptic vesicles releasing neurotransmitters. The theory of brain cell activation sets forth the principle, method and purpose of treatment of the physical gated ion channel diseases such as Alzheimer's disease, Parkinson's disease and other neural degeneration diseases, and indicates that the attempt to treat these diseases using pharmaceutical and chemical approaches could shake our confidence in conquering the diseases, and the application of physical approaches or combined application of physical and chemical approaches in the treatment of some major encephalopathy may be our main research direction in the future.

[Objective] Verification and application of the theory of brain cell activation. [Methods] Applying Transcranial magnetoelectric encephalopathy treatment instrument to the treatment of Neurodegenerative disease. including but not limited to: Parkinson's disease and Alzheimer's disease. [Results] Transcranial magnetoelectric encephalopathy treatment instrument，its double - center, randomized, double - blind clinical trial has been carried out at the national clinical trial base，it proves that the instrument is safe and effective. This instrument is especially suitable for the treatment of the following diseases: 1. It is suitable for the treatment of mild to moderate Parkinson's disease and can significantly improve resting tremor, rigidity, bradykinesia in patients with Parkinson’s disease and other symptoms. 2. It is suitable for the treatment of mild and moderate Alzheimer's disease and vascular dementia and can improve the mental state, cognitive behavior and self-care ability of daily life. 3. It is suitable for the treatment of mild to moderate depression and can obviously improve the main symptoms of depression, sleep disorder, anxiety and so on. 4. It is suitable for the treatment of cerebral apoplexy sequelae, cerebrovascular dementia and brain atrophy, it can activate the brain cells in the state of inhibition and mobilize the potential energy of the brain. [Conclusions] The theory of brain cell activation，It is applicable to encephalopathy and not limited to encephalopathy,according to this theory, the subject of "physical disease science" can be created.

The study of the action potential of cardiomyocytes is as important as the study of nerve fiber cells. The theoretical basis of the action potential of cardiomyocytes is the ionic theory formed by nerve fiber cells. Its core point of view: the decline phase of the action potential of cells is dominated by K+ outflow. Applying the principle of the K+ channel “origami windmill” model, the mechanism of action potential generation of nerve fiber cells has been reasonably explained, and a point contrary to the ion theory has been drawn: the phase of the action potential decline is dominated by K+ influx. Similarly, applying the principle of the K+ channel “origami windmill” model can also give a reasonable explanation for the mechanism of action potential generation of cardiomyocytes. The difference between cardiomyocyte action potential and nerve fiber cell: In addition to K+, Cl-, Na+, the process of generating cardiomyocyte action potential also involves the participation of Ca2+. Ca2+ inflow in the rising phase will shorten the depolarization time; Ca2+ inflow in the falling phase will prolong the repolarization time. K+, Ca2+ space substitution proportion: rotate into 2 K+, squeeze out 3 Ca2+, and 4 extra negative charges in the cell, the proportion is 2: 3: 4; Conversely, squeeze out 2 K+, rotate into 3 Ca2+, 4 extra positive charges the cells, the proportion is 3: 2: 4. Na+, Ca2+ space substitution proportion: rotate into 1 Na+, squeeze out 1 Ca2+, and 1 extra negative charges in the cell, the proportion is 1: 1:1; Conversely, rotate into 1 Ca2+, squeeze out 1 Na+, there is 1 more positive charge in the cell, and the proportion is 1: 1: 1. Application of “origami windmill” model principle, can reasonably explain the cardiomyocytes action potential generation mechanism, further proveding “origami windmill” the model theory, “the theory of dove-like particles”“the theory of braincell activation” of science.

Applying the K+ channel origami windmill model principle, the whole process of action potential generation of nerve fiber cells and cardiomyocytes is explained reasonably. Its core view is: cell action potential decline phase, dominated by influx of potassium ions. This is contrary to the core idea of the traditional theory—ionic theory. According to ionic theory, cell action potential decline phase, dominated by outflow of K+ ions. In the face of such two opposing views, the author traces back to the source, combing and commenting on the basic theoretical research on the production mechanism of cell bioelectricity generation and the results of classical basic experiments. And a series of enlightening viewpoints are produced：1. Ionic theory has its preexistence deficiency; 2. There are principle defects in GHK equation and H-H equation; 3. Ion channels may “same direction sharing”; 4. Sodium-potassium pumps, calcium pumps and so on May not exist. The thesis's Point is falsifiable. If “cell action potential decline stage, dominated by outflow of K+ ions” can be proved, all the points in this paper will not be true. On the contrary, the series of enlightening views in this paper will inevitably lead to a revolution in the field of life science. The viewpoint of this paper is not only closely related to the causes of human major diseases, treatment principles and methods, but also may have a profound impact on the future research direction of life science researchers.

In order to reasonably explain the phenomenon of cell bioelectricity, we proposed the conservation law of cell membrane area, established the ion inequality equation, and therefore paid attention to the mystery of “θ-τ”. We researched and analyzed the “θ-τ” mystery, discussed the parity non-conservation in weak interactions, suggested possible experiments to test the parity non-conservation in weak interactions, and gave our research and analysis conclusions: The parity non-conservation in weak interactions, is still a “conjecture”; The experimental scheme suggested in the papers by C. N. Yang et al. cannot determine whether the weak interaction can separate left and right, and it is impossible to directly answer whether θ and τ in the “θ-τ” mystery are the same particle; The Co60 β decay experiment such as C. S. Wu is a pseudo-mirror experiment, whether the experimental result violates parity conservation is only based on the assumption of C. N. Yang et al. In fact, experiments such as polarized Co60 did not overturn the so-called “law of parity conservation”. The mirror image principle does not have any physical meaning, does not correspond to any physical conservation quantity, and cannot be destroyed by any physical experiment. In the process of turning “mirror symmetry” and “mirror asymmetry” into so-called physical “common sense” and scientific “facts” respectively, the methods of transformation are “stealing concepts” and “circular argumentation”. The “θ-τ” mystery is a “man-made” mystery. θ and τ are two different particles, which may be the result of the same precursor particle being divided into two. The work of C. N. Yang, T. D. Lee, C. S. Wu et al. has brought quantum physicists from the “small black room” to the “bigger black room” or “smaller black room”. The right and wise choice is to go back through the door that came in. With the development of science today, it is time for some contents to reform from the bottom.

Alzheimer’s disease (AD) has been reported for more than 100 years since its first discovery in 1906. There has been no significant progress in the study of its real causes and pathogenesis. The viewpoint of this paper is a heuristic viewpoint based on brain cell activation theory under such background. In this paper, the pathogenesis of sporadic AD is discussed at molecular level by applying the principles of cell physics and biology. The purpose of this paper is to harmonize the existing theories of etiology of AD and to solve the source problems that have plagued the research field of neurodegenerative diseases for a long time. Conclusion: (1) Basic contents: excess cations are transferred from extracellular to intracellular. They compete position with potassium ions on the inner surface of cell membranes, thus abatementing the membrane potential, making action potential unable to activate calcium channels normally, which eventually leads to abnormal apoptosis of brain cells. Amyloid plaque is the remains of abnormal apoptotic brain cells. Amyloid plaque is the aggregation of amyloid spots by van der Waals force and electrostatic attraction, and its interstitium is amyloid protein. Brain cells consist of neurons, microglia and astrocytes in turn. Most of the spotted nuclei in the remains are cations. (2) Solutions: physical means, especially transcranial magnetoelectricity stimulation, should be the first choice for treatment. (3) Naming principles: because of the core point of view in this paper—The position of cation occupying potassium is the initiating factor of AD, so the etiology theory is named theory of dove-like particles. Take the Chinese idiom “Turtledove occupies the nest of magpies”. “Turtledove” represents the non-essential cation, “magpie” refers to the effective potassium ion, and “nest” refers to the position of the effective potassium ion.

本文提出的鉀離子通道模型，是一個獨立的功能單位，四條孔道螺旋同步單方向旋轉，轉運K+方式是被動單向的，對ATP沒有依賴性，不同于之前的“船槳”“螺旋槳”“旋轉門”等模型。作用機制是K+與孔道螺旋內帶正電荷的氨基酸形成的排斥力推動“風齒”后退“風車”旋轉，而K+通道孔徑大小隨著“風車”轉速的快慢而變化，決定著通道孔“開放”與“關閉”?！罢奂堬L車”模型，是應用細胞的生物物理學原理揭示K+通道運行機制，對與之相關的其它一些基礎性研究具有啟發意義，或許有助于從源頭上回答人類健康和疾病的基本生物學問題。